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KMID : 1003920060150010077
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Journal of Traditional Korean Medicine
2006 Volume.15 No. 1 p.77 ~ p.82
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Inhibitory Effects of the Ethanol Extract of Lavandula vera on Sebum Synthesis
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Park Si-Jun
Kim Ho-Min
Han Kyu-Soo
Seong Geum-Su
Shin Mee-Ran
Mun Yeun-Ja
Woo Won-Hong
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Abstract
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Lavandula vera is indispensable member of the herb family, used for perfumes and potpourri. Androgens have profound effects on the physiology of the sebaceous gland. Sebum is secreted due to the effect of androgen, which starts to be secreted at puberty. Using the human sebocyte cell line SZ95. the author investigated the inhibitory effect of Lavandula vera on the lipid production. Light microscopic finding were examined numerous cytoplasmic lipid droplets SZ95 cells by Oil red staining and lipid droplets were increased markedly by testosterone. On the other hand, combined treatment with Lavandula vera and testosterone resulted in a lower lipid droplets than with testosterone alone in a dose-dependent manner. These findings indicate that Lavandula vera acts antagonistically to testosterone and inhibits the lipid synthesis of SZ95 cells at the cellular level.
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KEYWORD
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Lavandula vera, Sebaceous lipid, Testosterone
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